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Good question. I'm not entirely sure. I don't have any 6" props to test with, but after measuring in my 3D program you will have 8mm of clearance between your props if you fly 6". That's pretty close together so it may be worth a shot. I can't guarantee how it will fly but if you're willing to test I'd love to hear how it works out. Also, in the future I'll get some 6" props and work on increasing the size of the frame a bit. Thanks.