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Hi, thank you for your questions, I guess acrylic is ok, although I am not sure, unheated glass definitely works though.

Flexible filament buckles when you push it, especially 1.75mm and especially Filaflex. You therefore need to have FULL filament support after the hobbed shaft and the hot end. a PTFE liner all the way down is what I use. Here is my modification : http://www.thingiverse.com/make:54389http://www.thingiverse.com/mak...

The Recreus hotend for Filaflex has an M6 thread so it is interchangeable on a Rep2 I believe. This is stainless steel with a PTFE liner :
Then there is the extruder with filament support if you intend to print with Filaflex

by Recreus
Recreus direct drive
by Recreus
ORCA 0.43 Extruderderivate
by Gyrobot