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Thanks for your great design I will give it a shot soon.
I just wanted to leave a note about klipper firmware and you might consider taking it into your thing details or not. I think klipper firmware is maybe a worthwhile upgrade. Nevertheless from my point of view it should be mentioned that this also makes your printer somewhat heavily dependent on the functionality of your UART/USB connection. I have a Raspberry Pi 4 attached to my Ender 3 and as some other guys I ran into the problem of sporadic interruptions (same as described here: https://github.com/KevinOConnor/klipper/issues/1919). Throttling the connection speed and hoping it will work sounds not much of an improvement to me. Thus the print speed is directly related to the UART speed - I think it would be better to have a better CPU installed on the board. There are approaches to this: