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Great design. I've successfully printed in the 90 degree orientation and it came out much better than 45 degree.
One potential issue I can see is the nozzle is 18mm from the left duct but only 15mm from the right.
Why do you think that is and do you think it will cause issues with the part cooling?
Stock Ender 3 Pro.
EDIT: Looking at my own photo I can see the Hero Me base is too close to the right side of the hot end. Looks like I need to adjust that.