MakerBot Print is our newest print-prepration software, which supports native CAD files and STL assemblies,
allows you to interact with all your printers via the Cloud, and many other exciting new features.
It depends on what software you are using to slice the model for printing. I use Cura to slice and to reduce the amount of spool used I print with less infill(10-18%), only 2 lines of wall thickness. Try printing the large base upside down to reduce supports