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MakerBot Print is our newest print-prepration software, which supports native CAD files and STL assemblies,
allows you to interact with all your printers via the Cloud, and many other exciting new features.

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I dont use OctoPi myself but its an upgrade thats still on my todo list. I think there is no reason for it to not work. The thinm with the 2 in 2 out is that you dont need a large priming tower which is why i decided to go for it. Anyhow it is very difficult to adjust the two nozzles to be on the exact same level. It reqires some patience.